Vortrag: "Cross-talks between DNA damage and innate immunity"
Sprecher: Prof. Nelson Gekara, PhD, Laboratory for Molecular Medicine Sweden (MIMS), Umea, Sweden.
Wann: Donnerstag, 5. April 2018, 17:15 Uhr
Wo: Campus der Medizinischen Fakultät, Haus 10, Hörsaal Kinderklinik
Gastgeber: Prof. Dr. rer. nat. Andrea Kröger (OvGU, Institut für Medizinische Mikrobiologie und Krankenhaushygiene)
Weitere Informationen: The innate immune system provides the first line of defense against microbes and other foreign substances. Innate immune detection of and responsiveness to microbes is mediated by sets of receptors known as pattern recognition receptors (PRRs). PRRs include Toll-like receptors (TLRs), found on the cell surface or endosomal compartments and intracellular receptors such as NOD-like receptors (NLRs) and RIG-I-like receptors (RLRs) cytoplasmic DNA sensors. Activation of PRRs results in the production of a large set of proinflammatory cytokines and type I interferons (IFNs), which act concertedly to coordinate host defenses against foreign invasion. Although meant to protect the host, excessive or deregulated induction of these innate immune responses, can either lead to self-injury (e.g. during sepsis or autoimmune diseases). Therefore, in order to maintain an optimal balance between anti-microbial host defenses and protection from self-harm, PRR signaling pathways must be regulated tightly. The Gekara lab is interested in understanding the mechanisms that govern the regulation of PRRs signaling pathways and how the breakdown of such regulation may lead to inflammation or impair anti-microbial host defenses. In particular, they are interested in how DNA damage and the ubiquitin system modulate inflammatory responses.
Im Rahmen der gemeinsamen Seminarreihe des Sonderforschungsbereiches 854 und des Else Kröner-Forschungskollegs Magdeburg laden wir Sie herzlich zu diesem Vortrag ein.