Vortrag: "Specialization of Tregs in Th1 responses"

Sprecher: Prof. Dr. Nicole Joller, Institute of Experimental Immunology, University of Zurich

Wann: Donnerstag, 2. November 2017, 17:00 Uhr

Wo: Campus der Medizinischen Fakultät, Haus 10, Hörsaal Kinderklinik

Gastgeber: Prof. Dr. Andreas Müller (OvGU, Institut für Molekulare und Klinische Immunologie)

Weitere Informationen: Our understanding of host-pathogen interaction is primarily derived from studying how the immune system protects us from a single pathogen. In contrast, it is largely unknown how this response alters the body’s ability to respond to a second infectious agent or the susceptibility to autoimmunity or cancer. Prof. Joller's goal is to investigate the long-term effects of pathogenic challenges on future responses. Currently, her group is focusing on changes in the regulatory compartment of the adaptive immune system.

Specifically they aim to:
* Analyze how regulatory T cell (Treg) function and the composition of the Treg compartment are affected by different types of infections
* Determine how a genetically modified Treg compartment affects susceptibility to infections and autoimmunity
* Investigate how previous infections affect the susceptibility to an unrelated secondary challenge

To achieve this they use a wide variety of techniques including:
molecular and biochemical assays, cell culture, flow cytometry, microscopy, immunological assays, animal models (infectious and autoimmune)

Im Rahmen der gemeinsamen Seminarreihe des Sonderforschungsbereiches 854 und des Else Kröner-Forschungskollegs Magdeburg laden wir Sie herzlich zu diesem Vortrag ein.